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	eosinophilic esophagitis

Disease ID	175
Disease	eosinophilic esophagitis
Definition	Chronic ESOPHAGITIS characterized by esophageal mucosal EOSINOPHILIA. It is diagnosed when an increase in EOSINOPHILS are present over the entire esophagus. The reflux symptoms fail to respond to PROTON PUMP INHIBITORS treatment, unlike in GASTROESOPHAGEAL REFLUX DISEASE. The symptoms are associated with IgE-mediated hypersensitivity to food or inhalant allergens.
Synonym	chronic esophagitides, eosinophilic chronic esophagitis, eosinophilic eoe1 eosinophilic chronic esophagitides eosinophilic chronic esophagitis eosinophilic esophagitides eosinophilic esophagitis (disorder) eosinophilic esophagitis [disease/finding] eosinophilic oesophagitis esophagitides, eosinophilic esophagitides, eosinophilic chronic esophagitis, eosinophilic esophagitis, eosinophilic chronic esophagitis, eosinophilic, 1
Orphanet	ORPHANET:73247
OMIM	OMIM:610247
DOID	DOID:13922
ICD10	ICD10CM:K20.0
UMLS	C0341106
MeSH	D057765
SNOMED-CT	SNOMEDCT_US_2016_09_01:235599003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:15) C0017168 \| oesophageal reflux \| 5 C0017168 \| gastroesophageal reflux \| 5 C0017168 \| esophageal reflux \| 5 C0017168 \| esophageal reflux disease \| 4 C0007570 \| celiac disease \| 4 C0017168 \| gastroesophageal reflux disease \| 4 C0014850 \| esophageal atresia \| 3 C0034065 \| pulmonary embolism \| 1 C0004096 \| asthma \| 1 C0009782 \| connective tissue disorder \| 1 C0007789 \| cerebral palsy \| 1 C0016470 \| food allergy \| 1 C0004763 \| barrett's esophagus \| 1 C0016470 \| food hypersensitivity \| 1 C0009782 \| connective tissue disorders \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:16) 286046 \| XKR6 \| GWASCAT 1630 \| DCC \| GWASCAT 85480 \| TSLP \| CTD_human;GWASCAT 6778 \| STAT6 \| GWASCAT 10344 \| CCL26 \| CTD_human 440854 \| CAPN14 \| CTD_human;GWASCAT 57619 \| SHROOM3 \| GWASCAT 9127 \| P2RX6 \| GWASCAT 726 \| CAPN5 \| GWASCAT 11077 \| HSF2BP \| GWASCAT 60494 \| CCDC81 \| GWASCAT 23076 \| RRP1B \| GWASCAT 7077 \| TIMP2 \| GWASCAT 57576 \| KIF17 \| GWASCAT 126917 \| IFFO2 \| GWASCAT 84079 \| ANKRD27 \| GWASCAT
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:47) 2683 \| B4GALT1 \| 1.298 \| DISEASES 100885775 \| BANCR \| 2.129 \| DISEASES 440854 \| CAPN14 \| 5.619 \| DISEASES 1232 \| CCR3 \| 3.197 \| DISEASES 1237 \| CCR8 \| 1.183 \| DISEASES 912 \| CD1D \| 2.071 \| DISEASES 60437 \| CDH26 \| 3.077 \| DISEASES 222256 \| CDHR3 \| 2.404 \| DISEASES 27159 \| CHIA \| 1.211 \| DISEASES 10321 \| CRISP3 \| 1.88 \| DISEASES 64109 \| CRLF2 \| 2.437 \| DISEASES 414325 \| DEFB103A \| 1.85 \| DISEASES 55894 \| DEFB103B \| 1.85 \| DISEASES 100289462 \| DEFB4B \| 1.236 \| DISEASES 28955 \| DEXI \| 2.478 \| DISEASES 8909 \| ENDOU \| 2.534 \| DISEASES 2254 \| FGF9 \| 2.072 \| DISEASES 2312 \| FLG \| 3.558 \| DISEASES 50943 \| FOXP3 \| 1.465 \| DISEASES 55876 \| GSDMB \| 1.45 \| DISEASES 3055 \| HCK \| 1.088 \| DISEASES 3384 \| ICAM2 \| 1.093 \| DISEASES 3601 \| IL15RA \| 2.097 \| DISEASES 90865 \| IL33 \| 2.731 \| DISEASES 3652 \| IPP \| 1.101 \| DISEASES 102723508 \| KANTR \| 2.247 \| DISEASES 3851 \| KRT4 \| 1.234 \| DISEASES 79782 \| LRRC31 \| 3.471 \| DISEASES 7786 \| MAP3K12 \| 1.501 \| DISEASES 4354 \| MPP1 \| 2.291 \| DISEASES 26496 \| OR10A3 \| 1.757 \| DISEASES 54625 \| PARP14 \| 3.029 \| DISEASES 5334 \| PLCL1 \| 2.135 \| DISEASES 10631 \| POSTN \| 3.578 \| DISEASES 11251 \| PTGDR2 \| 2.472 \| DISEASES 5831 \| PYCR1 \| 1.208 \| DISEASES 27181 \| SIGLEC8 \| 3.019 \| DISEASES 6949 \| TCOF1 \| 1.624 \| DISEASES 9414 \| TJP2 \| 1.17 \| DISEASES 387521 \| TMEM189 \| 1.109 \| DISEASES 642987 \| TMEM232 \| 1.353 \| DISEASES 7293 \| TNFRSF4 \| 1.417 \| DISEASES 85480 \| TSLP \| 5.014 \| DISEASES 134430 \| WDR36 \| 3.002 \| DISEASES 65986 \| ZBTB10 \| 2.09 \| DISEASES 84619 \| ZGPAT \| 1.305 \| DISEASES 10771 \| ZMYND11 \| 2.232 \| DISEASES
Locus	(Waiting for update.)

Disease ID	175
Disease	eosinophilic esophagitis
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:8) HP:0002020 \| Gastroesophageal reflux HP:0002031 \| Abnormality of the esophagus HP:0002015 \| Dysphagia HP:0100749 \| Chest pain HP:0005203 \| Spontaneous esophageal perforation HP:0005240 \| Esophageal obstruction HP:0002043 \| Esophageal stricture HP:0000969 \| Edema
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:19) HP:0002015 \| Swallowing difficulty \| 7 HP:0002020 \| Heartburn \| 7 HP:0002032 \| Esophageal atresia \| 4 HP:0002608 \| Celiac disease \| 4 HP:0012393 \| Allergy \| 3 HP:0001880 \| Eosinophilia \| 3 HP:0012531 \| Pain \| 2 HP:0010450 \| Narrowing of the esophagus \| 1 HP:0001907 \| Thromboembolic disease \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0002099 \| Asthma \| 1 HP:0100021 \| Cerebral palsy \| 1 HP:0100580 \| Barrett's esophagus \| 1 HP:0002955 \| Granulomatosis \| 1 HP:0002013 \| Emesis \| 1 HP:0002204 \| Pulmonary embolism \| 1 HP:0011968 \| Feeding difficulties \| 1 HP:0012735 \| Coughing \| 1 HP:0100749 \| Thoracic pain \| 1

Disease ID	175
Disease	eosinophilic esophagitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:5) C1546602 \| diverticulum C0426576 \| gastrointestinal symptoms C0014866 \| esophageal stenosis C0014860 \| esophageal perforation C0011168 \| dysphagia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0011168 \| dysphagia \| 7 C0014866 \| esophageal stenosis \| 1 C0014860 \| esophageal perforation \| 1 C0426576 \| gastrointestinal symptoms \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:20)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs11206830	25017104	8613	PPAP2B	umls:C0341106	GWASCAT	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	0.12	2014	PPAP2B	1	56494451	C	T
rs118086209	25017104	60494	CCDC81	umls:C0341106	GWASCAT	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	0.12	2014	CCDC81	11	86393453	T	G
rs149864795	25407941	440854	CAPN14	umls:C0341106	GWASCAT	Here we report genome-wide significant associations at four additional loci; c11orf30 and STAT6, which have been previously associated with both atopic and autoimmune diseases, and two EoE-specific loci, ANKRD27 that regulates the trafficking of melanogenic enzymes to epidermal melanocytes and CAPN14, that encodes a calpain whose expression is highly enriched in the oesophagus.	0.24	2014	CAPN14	2	31179541	G	A
rs167769	25407941	6778	STAT6	umls:C0341106	GWASCAT	Here we report genome-wide significant associations at four additional loci; c11orf30 and STAT6, which have been previously associated with both atopic and autoimmune diseases, and two EoE-specific loci, ANKRD27 that regulates the trafficking of melanogenic enzymes to epidermal melanocytes and CAPN14, that encodes a calpain whose expression is highly enriched in the oesophagus.	0.121085767	2014	STAT6	12	57109992	C	T
rs17004598	25017104	23076	RRP1B	umls:C0341106	GWASCAT	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	0.12	2014	HSF2BP;RRP1B	21	43658675	T	G
rs17004598	25017104	11077	HSF2BP	umls:C0341106	GWASCAT	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	0.12	2014	HSF2BP;RRP1B	21	43658675	T	G
rs1986734	20208534	57619	SHROOM3	umls:C0341106	GWASCAT	Common variants at 5q22 associate with pediatric eosinophilic esophagitis.	0.12	2010	SHROOM3	4	76499631	C	T
rs2075277	25017104	9127	P2RX6	umls:C0341106	GWASCAT	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	0.12	2014	P2RX6	22	21028193	T	C
rs2296225	25017104	57576	KIF17	umls:C0341106	GWASCAT	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	0.12	2014	KIF17	1	20704549	T	C
rs28530674	25017104	126917	IFFO2	umls:C0341106	GWASCAT	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	0.12	2014	IFFO2	1	18907640	A	G
rs2898261	25017104	286046	XKR6	umls:C0341106	GWASCAT	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	0.12	2014	XKR6	8	11101029	G	A,T
rs3744790	25017104	7077	TIMP2	umls:C0341106	GWASCAT	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	0.12	2014	TIMP2;KIAA1731NL	17	78897053	C	T
rs3806932	20208534	85480	TSLP	umls:C0341106	GWASCAT	These data implicate the 5q22 locus in the pathogenesis of EoE and identify TSLP as the most likely candidate gene in the region.	0.241628651	2010	TSLP	5	111069977	A	G
rs3806932	20208534	134430	WDR36	umls:C0341106	BeFree	We report association of EoE with variants at chromosome 5q22 encompassing TSLP and WDR36 (rs3806932, combined P = 3.19 x 10(-9)).	0.000542884	2010	TSLP	5	111069977	A	G
rs3806933	25017104	85480	TSLP	umls:C0341106	GWASCAT	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	0.241628651	2014	TSLP	5	111071044	C	T
rs3815700	25407941	84079	ANKRD27	umls:C0341106	GWASCAT	Here we report genome-wide significant associations at four additional loci; c11orf30 and STAT6, which have been previously associated with both atopic and autoimmune diseases, and two EoE-specific loci, ANKRD27 that regulates the trafficking of melanogenic enzymes to epidermal melanocytes and CAPN14, that encodes a calpain whose expression is highly enriched in the oesophagus.	0.12	2014	ANKRD27	19	32602346	T	C
rs61894547	25407941	56946	C11orf30	umls:C0341106	GWASCAT	Here we report genome-wide significant associations at four additional loci; c11orf30 and STAT6, which have been previously associated with both atopic and autoimmune diseases, and two EoE-specific loci, ANKRD27 that regulates the trafficking of melanogenic enzymes to epidermal melanocytes and CAPN14, that encodes a calpain whose expression is highly enriched in the oesophagus.	0.120271442	2014	C11orf30	11	76537586	C	T
rs77301713	25017104	726	CAPN5	umls:C0341106	GWASCAT	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	0.12	2014	CAPN5	11	77121400	G	A
rs77569859	25017104	440854	CAPN14	umls:C0341106	GWASCAT	We propose a model to explain the tissue-specific nature of EoE that involves the interplay of allergic sensitization with an EoE-specific, IL-13-inducible esophageal response involving CAPN14.	0.24	2014	CAPN14	2	31188421	T	C
rs9956738	25017104	1630	DCC	umls:C0341106	GWASCAT	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	0.12	2014	DCC	18	52414603	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:14)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
3	176030096	rs6799767	G	T	rs6799767	20208534	4.00E-07	NA	1.49	[1.18-1.85]	181 European descent adolescent cases; 1,974 European descent adolescent controls	European(2155)	ALL(2155)	EUR(2155)	ALL(2155)	Eosinophilic esophagitis (pediatric)	HPOID:0100633	Esophagitis	DOID:13922	eosinophilic esophagitis	D057765	Eosinophilic Esophagitis	EFOID:0004594	childhood eosinophilic esophagitis	Esophagitis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
4	77418681	rs13106227	G	A	rs13106227	20208534	4.00E-06	NA	1.52	[1.20-1.92]	181 European descent adolescent cases; 1,974 European descent adolescent controls	European(2155)	ALL(2155)	EUR(2155)	ALL(2155)	Eosinophilic esophagitis (pediatric)	HPOID:0100633	Esophagitis	DOID:13922	eosinophilic esophagitis	D057765	Eosinophilic Esophagitis	EFOID:0004594	childhood eosinophilic esophagitis	Esophagitis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
4	77420784	rs1986734	C	T	rs1986734	20208534	1.00E-06	NA	1.54	[1.22-1.89]	181 European descent adolescent cases; 1,974 European descent adolescent controls	European(2155)	ALL(2155)	EUR(2155)	ALL(2155)	Eosinophilic esophagitis (pediatric)	HPOID:0100633	Esophagitis	DOID:13922	eosinophilic esophagitis	D057765	Eosinophilic Esophagitis	EFOID:0004594	childhood eosinophilic esophagitis	Esophagitis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
5	81939318	rs1032757	G	A	rs1032757	20208534	2.00E-06	NA	1.96	[1.40-2.74]	181 European descent adolescent cases; 1,974 European descent adolescent controls	European(2155)	ALL(2155)	EUR(2155)	ALL(2155)	Eosinophilic esophagitis (pediatric)	HPOID:0100633	Esophagitis	DOID:13922	eosinophilic esophagitis	D057765	Eosinophilic Esophagitis	EFOID:0004594	childhood eosinophilic esophagitis	Esophagitis	rs1032757-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
5	110405675	rs3806932	A	G	rs3806932	20208534	3.00E-09	NA	1.85	NA	181 European descent adolescent cases; 1,974 European descent adolescent controls	European(2155)	ALL(2155)	EUR(2155)	ALL(2155)	Eosinophilic esophagitis (pediatric)	HPOID:0100633	Esophagitis	DOID:13922	eosinophilic esophagitis	D057765	Eosinophilic Esophagitis	EFOID:0004594	childhood eosinophilic esophagitis	Esophagitis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
6	58308955	rs9500256	G	A	rs9500256	20208534	5.00E-06	NA	2.04	[1.52-2.70]	181 European descent adolescent cases; 1,974 European descent adolescent controls	European(2155)	ALL(2155)	EUR(2155)	ALL(2155)	Eosinophilic esophagitis (pediatric)	HPOID:0100633	Esophagitis	DOID:13922	eosinophilic esophagitis	D057765	Eosinophilic Esophagitis	EFOID:0004594	childhood eosinophilic esophagitis	Esophagitis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
8	99088581	rs13278732	C	T	rs13278732	20208534	6.00E-06	NA	1.31	[1.04-1.65]	181 European descent adolescent cases; 1,974 European descent adolescent controls	European(2155)	ALL(2155)	EUR(2155)	ALL(2155)	Eosinophilic esophagitis (pediatric)	HPOID:0100633	Esophagitis	DOID:13922	eosinophilic esophagitis	D057765	Eosinophilic Esophagitis	EFOID:0004594	childhood eosinophilic esophagitis	Esophagitis	rs13278732-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
8	121694650	rs11989782	C	A	rs11989782	20208534	7.00E-06	NA	1.53	[1.21-1.93]	181 European descent adolescent cases; 1,974 European descent adolescent controls	European(2155)	ALL(2155)	EUR(2155)	ALL(2155)	Eosinophilic esophagitis (pediatric)	HPOID:0100633	Esophagitis	DOID:13922	eosinophilic esophagitis	D057765	Eosinophilic Esophagitis	EFOID:0004594	childhood eosinophilic esophagitis	Esophagitis	rs11989782-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
10	85422854	rs2224865	G	T	rs2224865	20208534	9.00E-06	NA	1.44	[1.15-1.79]	181 European descent adolescent cases; 1,974 European descent adolescent controls	European(2155)	ALL(2155)	EUR(2155)	ALL(2155)	Eosinophilic esophagitis (pediatric)	HPOID:0100633	Esophagitis	DOID:13922	eosinophilic esophagitis	D057765	Eosinophilic Esophagitis	EFOID:0004594	childhood eosinophilic esophagitis	Esophagitis	rs2224865-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
11	95422867	rs1939875	A	G	rs1939875	20208534	3.00E-06	NA	1.54	[1.22-1.93]	181 European descent adolescent cases; 1,974 European descent adolescent controls	European(2155)	ALL(2155)	EUR(2155)	ALL(2155)	Eosinophilic esophagitis (pediatric)	HPOID:0100633	Esophagitis	DOID:13922	eosinophilic esophagitis	D057765	Eosinophilic Esophagitis	EFOID:0004594	childhood eosinophilic esophagitis	Esophagitis	rs1939875-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
12	57503775	rs167769	C	T	rs167769	20208534	2.00E-06	NA	1.36	[1.10-1.69]	181 European descent adolescent cases; 1,974 European descent adolescent controls	European(2155)	ALL(2155)	EUR(2155)	ALL(2155)	Eosinophilic esophagitis (pediatric)	HPOID:0100633	Esophagitis	DOID:13922	eosinophilic esophagitis	D057765	Eosinophilic Esophagitis	EFOID:0004594	childhood eosinophilic esophagitis	Esophagitis	rs167769-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
16	84578241	rs371915	A	G	rs371915	20208534	2.00E-08	NA	1.9	[1.44-2.50]	181 European descent adolescent cases; 1,974 European descent adolescent controls	European(2155)	ALL(2155)	EUR(2155)	ALL(2155)	Eosinophilic esophagitis (pediatric)	HPOID:0100633	Esophagitis	DOID:13922	eosinophilic esophagitis	D057765	Eosinophilic Esophagitis	EFOID:0004594	childhood eosinophilic esophagitis	Esophagitis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
17	68291133	rs6501384	C	T	rs6501384	20208534	6.00E-06	NA	1.41	[1.13-1.76]	181 European descent adolescent cases; 1,974 European descent adolescent controls	European(2155)	ALL(2155)	EUR(2155)	ALL(2155)	Eosinophilic esophagitis (pediatric)	HPOID:0100633	Esophagitis	DOID:13922	eosinophilic esophagitis	D057765	Eosinophilic Esophagitis	EFOID:0004594	childhood eosinophilic esophagitis	Esophagitis	rs6501384-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
18	28902322	rs7236477	A	G	rs7236477	20208534	7.00E-06	NA	2.22	[1.39-3.55]	181 European descent adolescent cases; 1,974 European descent adolescent controls	European(2155)	ALL(2155)	EUR(2155)	ALL(2155)	Eosinophilic esophagitis (pediatric)	HPOID:0100633	Esophagitis	DOID:13922	eosinophilic esophagitis	D057765	Eosinophilic Esophagitis	EFOID:0004594	childhood eosinophilic esophagitis	Esophagitis	rs7236477-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:7)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0005240	Esophageal obstruction	MP:0011509	dilated glomerular capillary	stretched or widened aperture of the luminal space of the small branching blood vessel in the kidney glomerulus that receives blood from the kidney afferent arteriole
HP:0002043	Esophageal stricture	MP:0013501	increased fibroblast apoptosis	increase in the timing or the number of fibroblast cells undergoing programmed cell death
HP:0000969	Edema	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0100749	Chest pain	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0005203	Spontaneous esophageal perforation	MP:0011160	dermal-epidermal separation	the appearance of gaps or clefts in the normally continuous junctional interface between the dermis and epidermis
HP:0002015	Dysphagia	MP:0020329	decreased capillary density	reduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0002020	Gastroesophageal reflux	MP:0014178	increased brain apoptosis	increase in the number of cells of the brain undergoing programmed cell death

Disease ID	175
Disease	eosinophilic esophagitis
Case	(Waiting for update.)